We wish to understand the mechanisms of virus-induced changes in nuclear structures, function, and dynamics.

Our studies elucidate nuclear import, intranuclear mobility, and nuclear export of parvoviruses and herpesvirus capsids to understand the biological processes of infection. We have shown that chromatin is marginalized toward the nuclear envelope. This restrictive barrier became more permissive at late infection, allowing herpesvirus capsid diffusion towards the nuclear envelope. We are also interested in infection-induced changes in the structure and function of the nucleolus and mitochondria.